![]() ![]() In particular, compounds that specifically inhibit some of the downstream isoprenoid biosynthesis enzymes have been developed and their effects in cancer models are emerging. While detailed in vivo data for many of these putative targets is lacking, there have been several breakthroughs in recent years that could facilitate further studies. Inhibition of these enzymes, from mevalonate kinase to geranylgeranyl diphosphate synthase, could be attractive as a single agent therapy or in combination with current agents for treatment of cancers in which isoprenylated proteins have been implicated. ![]() In addition to the reactions that are targeted in current clinical applications, there are other enzymes that have not been studied as extensively. This has drawn significant attention to inhibitors of protein prenyl transferases. The rho proteins are important for regulating cell motility, and also must be isoprenylated. For example, ras oncogenes are well known ras proteins are overexpressed in many human cancers, and these proteins must be isoprenylated to function. Due to the importance of core human isoprenoid biosynthesis for diverse cellular processes related to cancer cell growth and metastasis, inhibition of this pathway may produce beneficial anticancer consequences. Inhibitors of isoprenoid biosynthesis are widely used to treat human disease including statins and nitrogenous bisphosphonates. Overall, our model and methodology can be used to pinpoint key reactions, which, upon manipulation, may predict altered cholesterol levels and reveal insights into potential drug therapy targets under diseased conditions. A sensitivity analysis correctly uncovers the Hmgcr, Idi2 and Fdft1 sites that regulate cholesterol homeostasis. The model is capable of replicating the trends of relative cholesterol levels in Alzheimer's and Huntington's diseases and reliably simulated SLOS, desmosterolosis, and Dhcr14/Lbr knockout studies. To build the model the baseline mRNA expression levels of genes involved in cholesterol metabolism were obtained from the Allen Mouse Brain Atlas. The core metabolic reactions of cholesterol in the brain, particularly in the hippocampus, were simulated. We present a method to derive enzymatic kinetic values from mRNA expression levels for modeling biological networks without requiring further tuning. Expression levels of 15 genes altered in this study were used as a "molecular signature" in a validation study of an additional 26 subjects and predicted them as FSHD or control with 90% accuracy based on biceps and 80% accuracy based on deltoids.Īn important part of the challenge of building models of biochemical reactions is determining reaction rate constants that transform substrates into products. Controlling for a false-discovery rate of <0.25 reduced the number of differentially expressed genes in biceps to 188 and in deltoid to 7. For both muscle types, the expression differences were mild: using relaxed cutoffs for differential expression (fold change ≥1.2 nominal P value <0.01), we identified 191 and 110 genes differentially expressed between affected and control samples of biceps and deltoid muscle tissues, respectively, with 29 genes in common. Gene expression in two muscle types was analyzed using GeneChip Gene 1.0 ST arrays: biceps, which typically shows an early and severe disease involvement and deltoid, which is relatively uninvolved. To better understand the pathophysiology of FSHD and develop mRNA-based biomarkers of affected muscles, we compared global analysis of gene expression in two distinct muscles obtained from a large number of FSHD subjects and their unaffected first-degree relatives. The pathophysiology of FSHD is unknown and, as a result, there is currently no effective treatment available for this disease. Facioscapulohumeral muscular dystrophy (FSHD) is a progressive neuromuscular disorder caused by contractions of repetitive elements within the macrosatellite D4Z4 on chromosome 4q35. ![]()
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![]() ![]() Lorex Camera Lorex cloud storage features Free cloud storage Here’s what we thought of it (and hint: Lorex is one of our top picks for a reason). That said, we wanted to see if Lorex can truly be called a top security camera brand, so we bought a security camera system and tested it for a few weeks. It can also be confusing shopping for Lorex, as there are hundreds of options (not necessarily a bad thing though!). It favors local video storage using DVRs and NVRs over cloud storage, for example, which means if your recorder is damaged, you could lose valuable footage. ![]() ![]() From 4K UltraHD cameras to cameras with security lights and person detection, Lorex has everything.īut Lorex is not without a few downsides. Many of Lorex’s cameras are affordable, and they feature the latest in security camera technology. With tough as nails security cameras, Lorex is a trusted brand that offers hundreds of different security camera options. With video resolutions ranging from 1080p to 4K HD, superb night vision, and on-location video storage through DVRs and NVRs, you’ll enjoy professional-grade home security equipment without the high monthly fees. That means that if we had a problem with our system outside of those working hours, we were out of luck. Customer Service: Customer service was open Monday through Saturday from 11:00 AM until 10:00 PM EST.That wasn’t a deal-breaker for us, but it’s important to note that without 24/7 professional monitoring, we were the ones responsible for calling for help in the event of an emergency. There was no option for 24/7 monitoring from professionals. No Professional Monitoring: This is a system that we had to monitor completely on our own using the Lorex App.If we didn’t want to do the installation ourselves, it was our responsibility to hire a professional installer through a third party. Installation: The installation process was left entirely to us and there was no option for professional installation through Lorex.Because we monitored the system on our phones, this feature was wonderful in eliminating unnecessary push notifications. But we didn’t get false notifications like if a branch moved, as our system had artificial intelligent features to detect only people and vehicles. People and Vehicle Detection: With advanced motion detectors, we were alerted when there was movement on our property.High Video Quality: The video quality is 4K, which is among the best of the best for security cameras.The only costs associated with this security system were the initial cost of the equipment or a fee for premium cloud storage, which was an optional add-on feature. No Required Monthly Fees: This was a huge pro for us, as we didn’t want to worry about long-term contracts or fees. ![]() ![]() ![]() Other Information Available About College Savings Calculators ![]() The three sections: Project Costs, Projected Savings and The Bottom Line will deliver an estimated cost of how much adjustment is needed in the amount of money to be saved to go to school. It also gives helpful tips for paying for school, especially if there is a projected shortfall. There are also areas in the calculator to input the number of years until school starts, interest, savings-to-date, and what amount someone is saving per month, if any.Īfter inputting whatever data the user has, the college savings calculator will determine the answers to all of those questions in an easy-to-read report, along with a graph displaying the amount of savings needed over time, along with inflation-adjusted tuition data. ![]() After determining the number of years of attendance, the user can input the percentage of savings they believe they’ll have by the time the student starts school. The college savings calculator allows the user to enter in an exact cost of school per year or use average figures for public and private 2- and 4-year schools. It also allows its user to input multiple scenarios to help them see how different savings plans will work. It allows someone to determine the amount of money needed for college, and calculate the amount of money you need to save to attend school. The college savings calculator allows you to research a number of financial-related questions related to the cost of attending schools. The College Board provides a handy college savings calculator at its website, /fincalc/college_savings.jsp. Determining Costs with a College Savings Calculator With costs on the increase, using a college savings calculator will help answer key questions about picking a school that one can afford. The center said that during the past decade tuition, room and board costs rose 32 percent at public schools and 24 percent at private schools. With the average price for tuition, room and board at a public school topping $12,200, and private schools averaging $31,233 for the 2008-2009 academic year, according to the National Center for Education Statistics, students need to factor in finances when they are attending school. ![]() ![]() I have had more than six confirmed sales, and maybe two or three more-but I don’t spend a lot of time pre-planning how the stand will be presented: I focused my arrangement on three central objects, which were the most visually arresting, and the display just fell into place. I brought Mayan objects, around 50, this year. I’m not someone who thinks about things like this a lot in advance. What have you brought with you this year? It’s attracting more foreigners, a few Russians and Americans, but predominantly I’m seeing a wider spectrum of Europeans each year. The décor and presentation of the event is also better than before. It has changed a lot and the quality of the fair has improved dealers are bringing better pieces. There is already an international interest in these objects. ![]() The next steps for the pre-Columbian market will be Mexico, Argentina and Brazil, which are developing rapidly economically and will become the markets of tomorrow. Now, all dealers are international and buy back objects sold before the second world war, or before the regulations were tightened. Where are buyers coming from? Are they mostly South American?īefore the regulations on the trade in pre-Columbian pieces were tightened, the most important dealers and collectors were Mexicans, who sold to international dealers. There is huge potential to increase the number of clients because of the growth of this kind of cross-collecting. They often buy several pieces, up to a dozen at a time, but they are also buying paintings, tapestries and antiquities from other places. There are people interested in pre-Columbian objects, but they are not necessarily real experts. Now, that kind of collector is very rare. When I began dealing, there were many collectors, meaning individuals who knew the speciality almost as well as the dealers. Certainly the behaviour of buyers has evolved. There are other private galleries, but in total there are only about ten dealers in the world.Īre there many buyers in the field? The number of galleries would suggest not. Now there are even fewer you have Merrin Gallery in New York, which presents very important pieces, and Stendahl Galleries in Los Angeles. When I opened, there was only one gallery in Belgium focusing on pre-Columbian art, some in New York and maybe three in Paris. I realised very few dealers specialised in this field. My motivation for opening the gallery in 1970 was simply the love of the objects. ![]() With affinity, you still have your judgement, which is important for an expert. It is not passion that drives me-with passion you become blind, you are so in love you cannot see the object clearly. But you have to distinguish between passion and affinity. ![]() Santo Micali: Mexican art is an art that delivers messages, it’s powerful, symbolic. The Art Newspaper: Why did you become interested in pre-Columbian art? Micali presented a stand of Mayan objects at this year’s Brussels Antiques and Fine Art Fair (Brafa, 21-29 January, see p72), where we spoke to him on the last day of the fair. ![]() He is also a member of the Syndicat National des Antiquaires (see p69), which promotes a common code of ethics, a topic of growing relevance given Mexico’s increasingly hardline stance on trading in items without solid provenance. Throughout his 40 years in the business, Micali has sourced a number of items for museums including the Janssen-Arts MAS collection, one of the most important pre-Columbian collections in Europe. Santo Micali, the manager and founder of Galerie Mermoz in Paris, is one of the few dealers to specialise in pre-Columbian, Mesoamerican and South American art-a field that is, he says, experiencing a new lease of life, thanks to the expanding interests of fine art and antiquities collectors. ![]() ![]() ![]() Just to be clear, when they said “variety” they meant the amount of weapons that are currently viable and overall just good to use, although I must say that when we talked about armors they did comment that many of them felt really bad comparing it with armors such as the Black Kat, Chaos and Padded armor sets. Although that was until she decided to join a guild and start to go through FSC runs, with their current gear they were kinda obsolete compared to literally everyone else, and then they decided to get the current meta for new players: Chaos set, Combuster and Blitz, which they did not seem to like as much, but agreed to be more comfortable to run FSC with, after some days, we discussed about the game’s balance, and they told me: “if there’s something that of this game that really pulls me back, it’s the lack of variety”, and I think this is a great problem for the game. Eventually, they actually decided to go for a Volcanic Pepperbox and a Wildfire, with a Shadowsun armor, since those were the weapons that although being certainly weak, made them go “Whoaaaaaaa! That’s so cool!”, and to be honest, this actually made me quite happy since this was a similar experience of mine when I first started the game, and made me feel some nostalgia. At first, I told her what was the meta and what was not, and then showed her some 5* weapons I had. I’m gonna start this section with a small anecdote.Ībout a year ago, I met a Spiral Knights player who just started to play the game, and I decided to help them on the side of grinding and knowing what gear to use. I think I would also improve the wiki servers too, they are just sooooo slow at times, that definitely needs an upgrade too. I know this could be expensive, but I think by just buying something slightly more powerful, and doing actions like removing all Haven instances except the English ones would improve things slightly (although I am not a professional on this stuff, so I’m not sure if this would truly help), and I know this sounds crazy, but to be honest any other language instance that is not the English one is next to empty, and you can even see many non-English speakers on the English instances anyways, so I think this would hurt nobody or, if it does, it would be an incredibly small amount of people. I think this is one of the first things that come to the mind of any player, since everyone could agree that servers can be noticeably unresponsive on missions, having many lagspikes and noticeable delay between a player making an action and that same action taking consequence. ![]() This one is pretty simple: Servers that are slightly faster and more reliable than the ones existing currently. ![]() With that said, this is what I believe SK definitely needs for it to be not only a better game, but to actually make people stay on the game for much longer, thus creating higher possibilities to make the game’s servers live for more time: I’d also love to see what other people have to say about this, so if you got any other thing/change the game currently needs, please state it on this forum post, although I’d like to ask that you only share what you think is absolutely important to be added or changed to the game currently, since discussing minor things here might make some posts just too big. And today I want to mostly talk about what I think Spiral Knights needs the most to achieve better quality, thus making people be temped to make its life last longer. Heya everyone! It is I: Mr.”FoV is viable”. ![]() ![]() ![]() For example, creating positive boundaries, establishing energising habits, and engaging in meaningful creative practices. There are quick fixes we might find helpful (breathing exercises, stepping away etc.) and longer-term conditions for more peace. This sort of tranquility emerges via processes, practices, and behaviours. We can take action to invite more calm and peace to our inner world. ![]() This kind of noise comes from our thoughts, feelings, and judgements. Serenity is not always an easy option when internal feedback loops kick in. And rather than adding to the noise, we can model an alternative approach that might inspire others. For example, we can diffuse it instead of retaliating in an escalating situation. Nurturing serenity from the inside out can also bring peace and gentleness to the world around us. We might ask ourselves: is this a common disturbance for us? What would need to change for the cause of noise to diminish? Or if the cause can’t be altered, how can we shift our position to the noise? How might we implement a boundary, change expectations, or move away from the noise source? The option of tranquility helps us examine the conditions of the disturbance-both in terms of the cause of the noise and our relationship with it. Maybe we can remind ourselves that this is temporary and the discomfort will pass. Perhaps all we can do is tell ourselves a story that invites understanding and tolerance (seeing the situation from another perspective). And we can then respond in a way that allows us to maintain as much composure and energy as possible. We can recognise how the noise has caused disturbance for us. This can include acknowledging the feelings that have been provoked within us. Whether that’s our proximity to it or the source itself, serenity can accept that things are as they are and choose our response to the noise. Serenity is the best option if we are unable to stop the cause of the noise. It enters through our eyes, ears, nose, mouth, and nerve endings. We sometimes find ourselves in noisy environments caused by an external disturbance we can’t control. There is always something we can consider on one side of the equation, even when there’s nothing we can do about it on the other. This distinction matters because it allows us to focus on different sides of the coin. Tranquility is about designing our environments, routines, lifestyles, and relationships to be deep sources of energy. Serenity is how we prepare to engage with the world around us in gentle ways. And our month of Tranquility focuses on the conditions of our external world. This is why we examine the relationship with our inner world during our month of Serenity. Tranquility aims to invite peace from the outside to the inside. Serenity helps peace flow from the inside to the outside. This is not a universal definition, just my way of separating two distinct concepts. The Difference Between Serenity and TranquilityĪlthough they are often used interchangeably, it can be helpful to distinguish between Serenity and Tranquility. And posits that serenity is a way of relating to, processing, and engaging with the everyday challenges of ordinary life and the shocks that hit us without warning. It helps us locate ourselves WITHIN the struggles. But the prayer paints an opposite picture. We might picture serenity as a harmonious life without conflict, suffering, and worry. This sometimes gets lost when we think of serenity as distancing from life’s struggles. It acknowledges serenity is not an absence of suffering, but rather it’s a recognition of our position WITHIN life’s disturbances. What I love about this prayer is that it sees serenity not as a destination but as a process. ![]() These are muscles we grow and sustain through rhythm and repetition. ![]() It carries three elements: acceptance, courage, and wisdom. And that peace is nurtured as we distinguish between the two and respond accordingly. It’s a recognition that some things (however scary it is to confront them) CAN be altered. It’s a call for mindful presence in accepting that some things (however much we wish they could) can’t be changed. It also demonstrates what I see as a difference between serenity and tranquility. Reinhold Niebuhr’s Serenity Prayer is an invitation for inner and outer peace. ![]() ![]() ![]() Take your search engine optimization to the next level with best-in-class link analysis, rank tracking, keyword difficulty scoring, local search optimization, and more. After our Google SEO Checker assesses your title tag and meta description, it evaluates your heading tags. Bulk Google Rank Checker by SEO Review Tools is a straightforward and worthwhile method to check google rankings for any platform. We love to experiment and design new and innovative tools related to search engine marketing, and now you can enjoy all of them. Explore our suite of premium, free SEO tools and online marketing software. ![]() Check snippets, heading tags, the presence of the Robots. TrueRanker is an accurate and reliable SEO tool that allows you to monitor keywords on Google in more than 40,000 different locations (Desktop + Mobile) and discover new ones that you had not detected, analyze the On-Page and PageSpeed optimization of any URL on your website and have under control the visibility of your domain, among other things. Analyze in depth the SEO of a web page and discover how to optimize it. TrueRanker is the Google Rank Checker that we always wanted to have, that helps us in our work every day and that you can use yourself to track your SEO performance, and grow organic traffic. Automate the process of working with copywriters and implement your content strategy in less time. However, we can tell you that the TrueRanker team has more than 15 years of experience in SEO and has managed websites with millions and millions of visits of organic traffic. We would be lying, since no one knows exactly how the world’s most used search engine works. ![]() We are not going to tell you that we know 100% how Google works, far from it. ![]() ![]() The major benefit is it increases updraft in windy conditions. Standard caps have screens for animals and help catch big sparks that fly up from the fire and into the flue. To keep things out, the cap is often fastened to the chimney's interior in situations when the flue is lower. They lay flush with the tile of the chimney flue and are screwed to the chimney. ![]() The standard chimney cap is the most common kind of chimney cap. This type of chimney cap is apt for older chimneys, not those seen in most newer houses. The damper mechanism is a simple one that is installed within the chimney, while a cable is routed inside the chimney to a lever normally mounted on the fireplace wall. Dampers stop cold air from blowing into the fireplace from outside. The integrated damper cap or mechanism is made for older fireplaces that do not have dampers inside the fireplace. It is ideal for people who struggle to get a decent draught on their fires, but it is also one of the most expensive chimney cap solutions. Depending on the weather and fire risk, owners may adjust the draft control. The cap has an electric fan with different speed settings. This is one of the most innovative designs for a chimney cap or crown as it comes with a fan that can be adjusted to several settings to help provide a good draft for the fire. To achieve a proper fit, the band-around caps must be installed by a professional. These chimney caps include an adjustable band that wraps around the chimney and a metal mesh skirt (which fits tightly around each corner of the flue). Stainless steel or aluminum is often used in their construction. It completely encloses the chimney and is tightly fitted around the bricks’ exterior. The best choice for an outside chimney is a band-around brick chimney cap. They are suitable for both masonry and prefabricated chimneys. Top-mount caps are best suited for chimneys with flues that rise beyond the crown therefore, consider this when choosing a cap for the chimney. Top mount chimney caps, also known as multi-flue chimney caps, are available in copper or stainless steel, with two different lid types, two different lid diameters, and four different screen heights. They work well in reducing the impact of downdrafts and are also quite simple to install. They may prevent animals and pests from entering the chimney in addition to blocking precipitation and falling leaves (via a mesh screen). Weathershielded caps can be utilized on both masonry and prefabricated chimneys. The main advantage is their corrosion resistance property and the ability to withstand very severe weather conditions. The weather shield chimney cap is often made of galvanized metals, aluminum, and stainless steel and is used particularly in places with high winds and colder temperatures. Weather Shield Chimney CrownĪ chimney cap often used in residential construction is known as a wind, storm, hurricane, or wind-resistant one. We also offer this same custom chimney cap with mesh in 8 inch, 12 inch, and 16 inch height to fit almost everyone's needs.The most commonly used types of chimney caps are: 1. This item comes in widths of 9 inches to 28 inches, and lengths of 9 inches to 58 inches, with a 10 inch mesh height. And we mean your needs - semi-custom means that you get to choose the length, height, mesh size and and overhang for yourself. This Gelco semi-custom, multi-flue chimney cap is built to take care of exactly your needs. But if you've got a chimney with multiple flues, it should be a bit more complicated, shouldn't it? Not here. Just a simple metal cage, sitting on top of your flue, that keep the rain and animals out, while the wire mesh lets smoke out and keep sparks in. Here's the thing, though - chimney caps help prevent all of those problems. Unless it's paying for water damage in your chimney, or having a wayward spark from your fireplace catching your roof on fire. ![]() *Please Note: This item is custom made by the manufacturer and can not be cancelled or returned once the order is placed unless the item is defective or damaged in transit.įew things in life are less fun than dealing with an unwanted animal visitor in your home. *Also Note: GSC Lids are embossed if the width is 14” or greater but lids that are 13” and less width have no embossing. * Please Note: These chimney caps are made to order and cannot be returned once purchased. Comes with both standard bolts and washers for easy installation.Trimmed-off screen barbs to protect the installer's hands.Cross-braced for additional structural strength.Durable stainless steel construction resists weather.Options of 3/4" mesh or 5/8" mesh (California compliant) for stricter spark protection. ![]() ![]() ![]() Her quartet experience has been filled with numerous awards within Sweet Adelines and the Harmony Sweepstakes Festival.Īllison has a life-long love of learning and looks forward to growing as a director, bringing that enthusiasm and passion to Potomac Harmony. On the chorus level within Sweet Adelines, Allison has always been an active member. MOUNTAIN VIEW, CA A Hazmat team joined a bomb squad in responding to a suspicious package at Google's Sunnyvale offices, the Sunnyvale Department of Public Safety reported Tuesday night. She was a member of the women’s chorus, Chamber Singers, Opera Workshop, and Soulstice a cappella group and served as the graduate director of the Virginia Tech men’s chorus. Allison studied voice and earned a Bachelor of Arts in Music Education with a focus on voice, and a Master of Arts in Curriculum and Instruction at Virginia Tech. ![]() She currently teaches elementary music and chorus in the Fairfax County Public School system. Potomac Harmony Chorus, Sweet Adelines International, is excited to introduce our new director, Allison Lynskey, and invites you to experience the excitement every Wednesday evening!Īllison has ten years of barbershop experience singing in a chorus and quartet, and is no stranger to other performing arts. Please drop by the website or find us in person. Promo code SPRING is valid for Spring Break or Summer Camps. Your young mover may discover an inner cat even sooner at Big Meow Spring Break Camp. Theme-based summer camps now open for enrollment start June 20- August 25. If you would like to dance, JFD teaching artists are there for you with classes for adults and young movers. MOUNTAIN VIEW (KRON) Mountain View Police responded to the Google campus on the 2000 block of Casey Avenue and evacuated the building due to a suspicious package. Use promo code BASK23 for a ticket discountĪtlas Performing Arts Center, 1333 H St NE Washington DC, March 3 at 7:30pm Suspicious package near Google building deemed not dangerous January 15, 2021, 11:21 AM Mountain View police say an investigation revealed that the package is not dangerous, but the bomb squad is still responding out of caution. Priore showcase new work with favorites by Jane Franklin, Ryan Carlough, Lauren DeVera. An envelope containing suspicious white powder was received Saturday at the campaign headquarters of the Republican nominee for governor in Arizona. The following week Jane Franklin Dance performs Present Moment BASK at Atlas INTERSECTIONS Festival. Mason Exhibition Arlington, 3601 Fairfax Drive Feb 25 at 1pm, 2pm, 3pm, FREE Poetry, written and performed by Bennie Herron interconnects movement, rhythm, cadence and art. The thirty minute performance features works by choreographers Lauren DeVera, Jane Franklin, and Kevin White. Both proximity and presence can be found at the February 25 live performances at Mason Exhibitions Arlington in response to the current exhibition Bennie Herron: Origin Stories. Jane Franklin Dance relishes an audience at eye level, performers and audience near enough to touch, and collaborations merging movement with sound or visual art. ![]() ![]() ![]() QuickTime 7.6.6 software required for QuickTime features.Īdobe After Effects CC 2020 Free DownloadĬlick on below button to start Adobe After Effects CC 2020 Free Download.Processor: Intel® Core™2 Duo or AMD Phenom® II processor 64-bit support. ![]()
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